This usually means a bad ISO. Try converting your ISO to CSO (Compressed ISO) using a tool like "PSP ISO Compressor". If that fails, find a different ISO dump (Redump.org verified checksums are best).
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Once extraction is complete, you will see a file ending in (e.g., Chili Con Carnage.iso ). This is your playable game file. Step 5: Launch the Game in PPSSPP Open the PPSSPP app . This usually means a bad ISO